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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-10-2
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pubmed:abstractText |
The mechanism by which sulindac causes regression of adenomas in patients with familial adenomatous polyposis (FAP) is unclear. Conflicting data on the drug's effects on colorectal epithelial proliferation have been reported. An alternative mechanism, and one not previously studied, is via induction of colorectal epithelial cell apoptosis (programmed cell death). This hypothesis was tested by studying the effects of sulindac on colorectal epithelial proliferation and apoptosis in patients with FAP.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
994-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7657130-Adenomatous Polyposis Coli,
pubmed-meshheading:7657130-Adult,
pubmed-meshheading:7657130-Analysis of Variance,
pubmed-meshheading:7657130-Apoptosis,
pubmed-meshheading:7657130-Cell Cycle,
pubmed-meshheading:7657130-Cell Division,
pubmed-meshheading:7657130-Colon,
pubmed-meshheading:7657130-Double-Blind Method,
pubmed-meshheading:7657130-Epithelium,
pubmed-meshheading:7657130-Female,
pubmed-meshheading:7657130-Flow Cytometry,
pubmed-meshheading:7657130-Humans,
pubmed-meshheading:7657130-Immunohistochemistry,
pubmed-meshheading:7657130-Male,
pubmed-meshheading:7657130-Middle Aged,
pubmed-meshheading:7657130-Multivariate Analysis,
pubmed-meshheading:7657130-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:7657130-Rectum,
pubmed-meshheading:7657130-Remission Induction,
pubmed-meshheading:7657130-Sulindac
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pubmed:year |
1995
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pubmed:articleTitle |
The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis.
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pubmed:affiliation |
Department of Medicine, Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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