Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-10-3
pubmed:abstractText
Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin's lymphoma characterized by the CD30+ large neoplastic cells and sometimes carries a t(2;5)(p23;q35). Recently, we found a novel hyperphosphorylated 80-kD protein tyrosine kinase, p80, in ALCLs with t(2;5). Subsequent cDNA cloning showed p80 to be a fusion protein of two genes, the novel tyrosine kinase gene and the nucleophosmin gene, in accordance with the sequence of the NPM/ALK gene (Morris et al, Science 263:1281, 1994). Meanwhile, the clinicopathologic features of p80-carrying ALCLs have remained unclear. Paraffin sections of 105 cases of ALCL were immunostained using anti-p80 antibody, and 30 of them were shown to express p80. Clinicopathologic comparison between p80-positive and -negative ALCLs showed that p80-positive cases occurred in a far younger patient age group (16.2 +/- 12.9 years; p80-negative cases, 51.0 +/- 22.3 years; P < .0001) and the patients showed a far better 5-year survival rate (79.8%; p80-negative group, 32.9%; P < .01). These data showed that p80-positive ALCL is a distinct entity both clinically and pathogenetically and should be differentiated from p80-negative ALCL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
86
pubmed:geneSymbol
NPM
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1954-60
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:7655022-Adolescent, pubmed-meshheading:7655022-Adult, pubmed-meshheading:7655022-Age Factors, pubmed-meshheading:7655022-Antigens, CD, pubmed-meshheading:7655022-Antigens, CD30, pubmed-meshheading:7655022-Chromosome Mapping, pubmed-meshheading:7655022-Chromosomes, Human, Pair 2, pubmed-meshheading:7655022-Chromosomes, Human, Pair 5, pubmed-meshheading:7655022-Gene Expression, pubmed-meshheading:7655022-Humans, pubmed-meshheading:7655022-Immunohistochemistry, pubmed-meshheading:7655022-Lymphoma, Large B-Cell, Diffuse, pubmed-meshheading:7655022-Middle Aged, pubmed-meshheading:7655022-Nuclear Proteins, pubmed-meshheading:7655022-Phosphoproteins, pubmed-meshheading:7655022-Phosphorylation, pubmed-meshheading:7655022-Protein-Tyrosine Kinases, pubmed-meshheading:7655022-Recombinant Fusion Proteins, pubmed-meshheading:7655022-Survival Rate, pubmed-meshheading:7655022-Translocation, Genetic
pubmed:year
1995
pubmed:articleTitle
Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity.
pubmed:affiliation
Department of Pathology, University of Tokyo, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't