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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-9-25
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pubmed:abstractText |
There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to 'generalized' epilepsies, and that most forms of 'partial' epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for partial epilepsy. This susceptibility gene maps to chromosome 10q, with a maximum two-point lod score for D10S192 of 3.99 at theta = 0.0. All affected individuals share a single haplotype for seven tightly linked contiguous markers; the maximum lod score for this haplotype is 4.83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-1619451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-1868801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-1901452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-1922810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-2492220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-2494041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-2780284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-2916582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-2918897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-3146924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-3162348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-6585139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-6790275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-7545953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-7647788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-7806245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-7906762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-807473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-8102508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-8317490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-8352275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7647791-8504780
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1061-4036
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
56-60
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:7647791-Adolescent,
pubmed-meshheading:7647791-Adult,
pubmed-meshheading:7647791-Chromosome Mapping,
pubmed-meshheading:7647791-Chromosomes, Human, Pair 10,
pubmed-meshheading:7647791-Epilepsies, Partial,
pubmed-meshheading:7647791-Female,
pubmed-meshheading:7647791-Genetic Linkage,
pubmed-meshheading:7647791-Genetic Markers,
pubmed-meshheading:7647791-Genotype,
pubmed-meshheading:7647791-Humans,
pubmed-meshheading:7647791-Male,
pubmed-meshheading:7647791-Middle Aged,
pubmed-meshheading:7647791-Pedigree
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pubmed:year |
1995
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pubmed:articleTitle |
Localization of a gene for partial epilepsy to chromosome 10q.
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pubmed:affiliation |
G. H. Sergievsky Center, School of Public Health, Columbia University, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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