|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1995-9-13
|
|
pubmed:abstractText |
Very late activation-2 (VLA-2) is an integrin receptor for laminin that consists of an alpha 2- and a beta 1-subunit. In human breast cancer, down-regulation of VLA-2 expression is related to positive nodal status. The functional significance of altered integrin expression in individual patients has never been investigated. To test the hypothesis that less adhesive primary breast cancer cells were predisposed to metastasize, variation in VLA-2 modulation of cell attachment to laminin with nodal status was studied.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0039-6060
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
118
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
245-50
|
|
pubmed:dateRevised |
2010-3-24
|
|
pubmed:meshHeading |
pubmed-meshheading:7638740-Adult,
pubmed-meshheading:7638740-Aged,
pubmed-meshheading:7638740-Aged, 80 and over,
pubmed-meshheading:7638740-Antibodies, Monoclonal,
pubmed-meshheading:7638740-Breast Neoplasms,
pubmed-meshheading:7638740-Cell Adhesion,
pubmed-meshheading:7638740-Female,
pubmed-meshheading:7638740-Humans,
pubmed-meshheading:7638740-Immunohistochemistry,
pubmed-meshheading:7638740-Laminin,
pubmed-meshheading:7638740-Lymph Nodes,
pubmed-meshheading:7638740-Middle Aged,
pubmed-meshheading:7638740-Neoplasm Metastasis,
pubmed-meshheading:7638740-Receptors, Laminin,
pubmed-meshheading:7638740-Receptors, Very Late Antigen
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Modulation of very late activation-2 laminin receptor function in breast cancer metastasis.
|
|
pubmed:affiliation |
Department of Surgery, St. Bartholomew's Hospital, London, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
