Linked Life Data

7630016

Source:http://linkedlifedata.com/resource/pubmed/id/7630016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1995-9-5
pubmed:abstractText
An increased rate of expression of Lewis group antigens, particularly Lewisb antigen, was observed in endometrial cancers compared with its expression in normal endometria. In order to elucidate the expression mechanism of Lewisb antigen in endometrial cancer, the level of fucosyltransferase (FT) was examined. The levels of alpha 1-2FT alpha 1-3FT and alpha 1-4FT were higher in endometrial cancer than those in normal endometrium. Endometrial cancer with a poor prognosis tended to react poorly to anti-endometrial cancer monoclonal antibody designated MSN-1, suggesting the possibility that the reactivity to MSN-1 is useful as a new prognostic factor for endometrial cancer. Cells of uterine endometrial cancer cell line SNG-II were classified into two groups according to their reactivity with MSN-1, whose antigen recognized is mainly Lewisb antigen. Using these classified cells of endometrial cancer cell line, it has revealed that the cells which strongly express H type antigen have more tendency to attach to endothelial cells and to cause metastasis than the cells which strongly express Lewisb antigen.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1753-9
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Abnormal expression of carbohydrate chain and its mechanism in endometrial cancer].
pubmed:affiliation
Department of Obstetrics and Gynecology, School of Medicine, Keio University.
pubmed:publicationType
Journal Article, English Abstract, Review