Linked Life Data

7629336

Source:http://linkedlifedata.com/resource/pubmed/id/7629336

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-9-6
pubmed:abstractText
Casein phosphopeptides (CPP) stabilize calcium phosphate through the formation of casein-phosphopeptide amorphous calcium-phosphate complexes (CPP-CP). The ability of CPP-CP to reduce caries activity was investigated by use of specific-pathogen-free rats inoculated with Streptococcus sobrinus. The animals consumed a defined cariogenic diet free of dairy products. Solutions (100 microL) of the CPP-CP (0.1, 0.2, 0.5, 1.0% w/v) were applied to the animals' molar teeth twice daily. Other groups of animals received solutions containing 500 ppm F, the non-phosphorylated peptides of a casein tryptic digest (0.5% w/v), or the calcium-phosphate complex of a synthetic octapeptide, Ac-Glu-Ser(P)-Ile-Ser(P)-Ser(P)-Ser(P)-Glu-Glu-NHMe, corresponding to the common sequence in the CPP. The CPP-CP significantly reduced caries activity in a dose-response fashion, with 1.0% CPP-CP producing 55% and 46% reductions in smooth surface and fissure caries activity, respectively, being similar to that of 500 ppm F. The anticariogenic effects of CPP-CP and fluoride were additive, since animals receiving 0.5% CPP-CP plus 500 ppm F had significantly lower caries activity than those animals receiving either CPP-CP or fluoride alone. The tryptic digest of casein with the phosphopeptides selectively removed showed no anticariogenic activity. The synthetic octapeptide-calcium phosphate complex significantly reduced caries activity, confirming that this calcium-phosphate-stabilizing portion of the casein phospho-peptides is associated with anticariogenicity. The CPP-CP did not significantly affect the level of S. sobrinus in fissure plaque.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-0345
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1272-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:7629336-Amino Acid Sequence, pubmed-meshheading:7629336-Analysis of Variance, pubmed-meshheading:7629336-Animals, pubmed-meshheading:7629336-Calcium Phosphates, pubmed-meshheading:7629336-Cariostatic Agents, pubmed-meshheading:7629336-Caseins, pubmed-meshheading:7629336-Dental Caries, pubmed-meshheading:7629336-Dental Plaque, pubmed-meshheading:7629336-Diet, Cariogenic, pubmed-meshheading:7629336-Dose-Response Relationship, Drug, pubmed-meshheading:7629336-Drug Synergism, pubmed-meshheading:7629336-Female, pubmed-meshheading:7629336-Fluorides, pubmed-meshheading:7629336-Male, pubmed-meshheading:7629336-Molecular Sequence Data, pubmed-meshheading:7629336-Peptide Fragments, pubmed-meshheading:7629336-Peptides, pubmed-meshheading:7629336-Phosphopeptides, pubmed-meshheading:7629336-Rats, pubmed-meshheading:7629336-Rats, Sprague-Dawley, pubmed-meshheading:7629336-Specific Pathogen-Free Organisms, pubmed-meshheading:7629336-Statistics, Nonparametric, pubmed-meshheading:7629336-Streptococcus sobrinus, pubmed-meshheading:7629336-Tooth Remineralization
pubmed:year
1995
pubmed:articleTitle
Anticariogenicity of calcium phosphate complexes of tryptic casein phosphopeptides in the rat.
pubmed:affiliation
Biochemistry and Molecular Biology Unit, School of Dental Science, Faculty of Medicine, University of Melbourne, Australia.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't