Linked Life Data

7618294

Source:http://linkedlifedata.com/resource/pubmed/id/7618294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-8-22
pubmed:abstractText
Penetration of Ca2+ into neuron have been shown earlier to be mainly responsible for the cell habituation to repeated intracellular stimulation by impulse depolarizing current. Considering the key role of nitric oxide (NO) in regulation of intracellular Ca2+ turnover, effects of exogenous nitrite NaNO2, used as a source of NO, on plasticity properties of the electrostimulated membrane were studied in the identified habituating and non-habituating neurones of snail (Gastropoda) brain. The sodium nitrite 10(-6)-10(-4) M was found to inhibit, with a latent period 10-30 min, the ability of the habituating neurones to get accustomed to stimulation; this phenomenon was oscillatory. The concentration of nitrite 10(-3) M affected irreversibly the habituation. Serotonin potentiated the inhibitory effect of nitrite on habituation and vice versa nitrite augmented the serotonin effect on habituation of the same neurones. The exogenous nitrite sensitized the non-habituating neurones to intracellular stimulation. These data suggest that nitrite affects the plasticity properties of the electrostimulated neurone membrane. Besides, these results and well-known properties of NO allowed one to assume that NO-dependent regulation of intracellular Ca2+ was responsible for the phenomenon observed as well as that NO- and serotoninergic systems appear to interact in the snail brain.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0042-8809
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
20-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Nitrites block the Ca-dependent habituation of neurons at the level of an electroexcitable membrane: a possible role for nitric oxide].
pubmed:publicationType
Journal Article, English Abstract