| pubmed-article:7608561 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C0439596 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:7608561 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:7608561 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7608561 | pubmed:dateCreated | 1995-8-16 | lld:pubmed |
| pubmed-article:7608561 | pubmed:abstractText | IL-1 beta is a cytokine generally considered to be a major component involved in the pathogenesis of rheumatoid arthritis and other inflammatory diseases. Of the agents found in high concentrations in inflamed rheumatoid arthritis joints, TNF-alpha is among the most strongly implicated as an in vivo inducer of IL-1 beta. Here we report that in human PBMC and in a stable transfectant of the promonocytic cell line, THP-1, TNF-alpha indeed appears to be an inducer of IL-1 beta production, but only in the presence of dibutyryl cAMP or agents such as the PG that elevate intracellular cAMP levels. This TNF-alpha/cAMP pathway regulates IL-1 beta production at the level of transcription and requires a cAMP response element located between -2762 and -2755 bp in the upstream regulatory sequence of IL-1 beta. Because PG, which are known to elevate cAMP levels in vivo, and TNF-alpha are both found in significant quantities in the synovial fluid of rheumatoid arthritis joints, the observed synergistic up-regulation in IL-1 beta synthesis by TNF-alpha/cAMP (PG) may provide valuable insight into the potential pathways involved in the continuous production of IL-1 beta in the chronically inflamed joint. | lld:pubmed |
| pubmed-article:7608561 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7608561 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7608561 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7608561 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7608561 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7608561 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7608561 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7608561 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7608561 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7608561 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7608561 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7608561 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7608561 | pubmed:author | pubmed-author:VergheseM WMW | lld:pubmed |
| pubmed-article:7608561 | pubmed:author | pubmed-author:ChandraGG | lld:pubmed |
| pubmed-article:7608561 | pubmed:author | pubmed-author:TaylorJ DJD | lld:pubmed |
| pubmed-article:7608561 | pubmed:author | pubmed-author:GrayJ GJG | lld:pubmed |
| pubmed-article:7608561 | pubmed:author | pubmed-author:KostT ATA | lld:pubmed |
| pubmed-article:7608561 | pubmed:author | pubmed-author:RomerM AMA | lld:pubmed |
| pubmed-article:7608561 | pubmed:author | pubmed-author:FurdonP JPJ | lld:pubmed |
| pubmed-article:7608561 | pubmed:author | pubmed-author:HanelineS ASA | lld:pubmed |
| pubmed-article:7608561 | pubmed:author | pubmed-author:LorenzJ JJJ | lld:pubmed |
| pubmed-article:7608561 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7608561 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7608561 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:7608561 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7608561 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7608561 | pubmed:pagination | 836-44 | lld:pubmed |
| pubmed-article:7608561 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:7608561 | pubmed:meshHeading | pubmed-meshheading:7608561-... | lld:pubmed |
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| pubmed-article:7608561 | pubmed:meshHeading | pubmed-meshheading:7608561-... | lld:pubmed |
| pubmed-article:7608561 | pubmed:meshHeading | pubmed-meshheading:7608561-... | lld:pubmed |
| pubmed-article:7608561 | pubmed:meshHeading | pubmed-meshheading:7608561-... | lld:pubmed |
| pubmed-article:7608561 | pubmed:meshHeading | pubmed-meshheading:7608561-... | lld:pubmed |
| pubmed-article:7608561 | pubmed:meshHeading | pubmed-meshheading:7608561-... | lld:pubmed |
| pubmed-article:7608561 | pubmed:meshHeading | pubmed-meshheading:7608561-... | lld:pubmed |
| pubmed-article:7608561 | pubmed:meshHeading | pubmed-meshheading:7608561-... | lld:pubmed |
| pubmed-article:7608561 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7608561 | pubmed:articleTitle | A cyclic adenosine 3',5'-monophosphate signal is required for the induction of IL-1 beta by TNF-alpha in human monocytes. | lld:pubmed |
| pubmed-article:7608561 | pubmed:affiliation | Department of Cell Physiology, Glaxo Wellcome, Inc., Research Triangle Park, NC 27709, USA. | lld:pubmed |
| pubmed-article:7608561 | pubmed:publicationType | Journal Article | lld:pubmed |
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