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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-8-17
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40600,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40601,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40602,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40603,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40604,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40605,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40606,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40607,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40608,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L40609,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L42244,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L42636
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pubmed:abstractText |
The human malaria parasite Plasmodium falciparum evades host immunity by varying the antigenic and adhesive character of infected erythrocytes. We describe a large and extremely diverse family of P. falciparum genes (var) that encode 200-350 kDa proteins having the expected properties of antigenically variant adhesion molecules. Predicted amino acid sequences of var genes show a variable extracellular segment with domains having receptor-binding features, a transmembrane sequence, and a terminal segment that is a probable submembrane anchor. There are 50-150 var genes on multiple parasite chromosomes, and some are in clustered arrangements. var probes detect two classes of transcripts in steady-state RNA: 7-9 kb var transcripts, and an unusual family of 1.8-2.4 kb transcripts that may be involved in expression or rearrangements of var genes.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
82
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pubmed:geneSymbol |
var
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89-100
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7606788-Amino Acid Sequence,
pubmed-meshheading:7606788-Animals,
pubmed-meshheading:7606788-Antigenic Variation,
pubmed-meshheading:7606788-Antigens, Protozoan,
pubmed-meshheading:7606788-Base Sequence,
pubmed-meshheading:7606788-Cell Adhesion Molecules,
pubmed-meshheading:7606788-Erythrocytes,
pubmed-meshheading:7606788-Gene Rearrangement,
pubmed-meshheading:7606788-Genes, Protozoan,
pubmed-meshheading:7606788-Humans,
pubmed-meshheading:7606788-Molecular Sequence Data,
pubmed-meshheading:7606788-Multigene Family,
pubmed-meshheading:7606788-Plasmodium falciparum,
pubmed-meshheading:7606788-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:7606788-RNA, Messenger,
pubmed-meshheading:7606788-RNA, Protozoan,
pubmed-meshheading:7606788-Restriction Mapping,
pubmed-meshheading:7606788-Sequence Alignment,
pubmed-meshheading:7606788-Sequence Analysis, DNA,
pubmed-meshheading:7606788-Sequence Homology, Amino Acid
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pubmed:year |
1995
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pubmed:articleTitle |
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes.
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pubmed:affiliation |
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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