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rdf:type |
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lifeskim:mentions |
umls-concept:C0023798,
umls-concept:C0040649,
umls-concept:C0122111,
umls-concept:C0220905,
umls-concept:C0332453,
umls-concept:C0949662,
umls-concept:C1514562,
umls-concept:C1521761,
umls-concept:C1708111,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
1
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|
pubmed:dateCreated |
1995-8-17
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pubmed:databankReference |
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pubmed:abstractText |
Lipomas are one of the most common mesenchymal neoplasms in humans. They are characterized by consistent cytogenetic aberrations involving chromosome 12 in bands q14-15. Interestingly, this region is also the site of rearrangement for other mesenchymally derived tumors. This study demonstrates that HMGI-C, an architectural factor that functions in transcriptional regulation, has been disrupted by rearrangement at the 12q14-15 chromosomal breakpoint in lipomas. Chimeric transcripts were isolated from two lipomas in which HMGI-C DNA-binding domains (AT hook motifs) are fused to either a LIM or an acidic transactivation domain. These results, identifying a gene rearranged in a benign neoplastic process that does not proceed to a malignancy, suggest a role for HMGI-C in adipogenesis and mesenchyme differentiation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0092-8674
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
82
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pubmed:geneSymbol |
HMGI-C
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-65
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7606786-Amino Acid Sequence,
pubmed-meshheading:7606786-Base Sequence,
pubmed-meshheading:7606786-Chromosome Mapping,
pubmed-meshheading:7606786-Chromosomes, Human, Pair 12,
pubmed-meshheading:7606786-Cloning, Molecular,
pubmed-meshheading:7606786-DNA, Neoplasm,
pubmed-meshheading:7606786-DNA-Binding Proteins,
pubmed-meshheading:7606786-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:7606786-Gene Rearrangement,
pubmed-meshheading:7606786-HMGA2 Protein,
pubmed-meshheading:7606786-High Mobility Group Proteins,
pubmed-meshheading:7606786-Humans,
pubmed-meshheading:7606786-Lipoma,
pubmed-meshheading:7606786-Mesoderm,
pubmed-meshheading:7606786-Molecular Sequence Data,
pubmed-meshheading:7606786-RNA, Messenger,
pubmed-meshheading:7606786-RNA, Neoplasm,
pubmed-meshheading:7606786-Transcription, Genetic,
pubmed-meshheading:7606786-Transcriptional Activation
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pubmed:year |
1995
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|
pubmed:articleTitle |
Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains.
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pubmed:affiliation |
Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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