Linked Life Data

7594715

Source:http://linkedlifedata.com/resource/pubmed/id/7594715

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-12-28
pubmed:abstractText
Fewer Mycobacterium tuberculosis colony-forming units given by aerosol were substantially more virulent for mice than much larger numbers inoculated intravenously (iv), as shown by a faster rate of bacillary growth in the lungs and much shorter survival of the host. Earlier death of mice infected by aerosol was associated with faster development of lung pathology, even though the number of M. tuberculosis given iv resulted in the same number of bacilli initially implanting in the lungs as the number given by aerosol. Mice depleted of CD4 T cells died of infection much sooner than immunocompetent mice but at about the same time after being infected via either route. The results indicate that a small number of M. tuberculosis colony-forming units given by aerosol is less immunogenic than a larger number given iv.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
172
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1550-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Mycobacterium tuberculosis is strikingly more virulent for mice when given via the respiratory than via the intravenous route.
pubmed:affiliation
Trudeau Institute, Inc., Saranac Lake, NY 12983, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't