Linked Life Data

7591287

Source:http://linkedlifedata.com/resource/pubmed/id/7591287

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-12-28
pubmed:abstractText
Heparin-steroid conjugates have been prepared by linking a non-anti-coagulating derivative of heparin, which binds to endothelial cells, to an angiostatic steroid, which suppresses endothelial cell division. One such conjugate, heparin adipic hydrazide (HAH) linked to cortisol, has previously been shown to inhibit both angiogenesis and the growth of solid tumors in mice. In the present study, heparin hydrazide (HH) was linked to tetrahydro S, tetrahydrocortisone and tetrahydrocortisol, which are devoid of glucocorticoid and mineralocorticoid activity and hence were predicted to have low toxicity to animals. The tetrahydro steroid conjugates were compared with the cortisol conjugate for therapeutic effectiveness against solid Lewis lung carcinoma growing in mice. HAH-cortisol reduced tumor growth by up to 75% whereas a simple mixture of HAH and cortisol was not significantly inhibitory. In contrast to HAH-cortisol, the 3 tetrahydro steroid conjugates did not significantly inhibit tumor growth. The differences in anti-tumor properties of the conjugates correlated with their ability to inhibit angiogenesis in a Matrigel implant model in mice. The tetrahydro steroid conjugates did not significantly inhibit angiogenesis whereas HAH-cortisol inhibited angiogenesis by greater than 90%. Therefore, HAH-cortisol is the most effective heparin-steroid conjugate so far developed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
694-701
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7591287-Animals, pubmed-meshheading:7591287-Anticoagulants, pubmed-meshheading:7591287-Antineoplastic Agents, pubmed-meshheading:7591287-Carcinoma, Lewis Lung, pubmed-meshheading:7591287-Cell Division, pubmed-meshheading:7591287-Collagen, pubmed-meshheading:7591287-DNA, Neoplasm, pubmed-meshheading:7591287-Drug Combinations, pubmed-meshheading:7591287-Endothelium, Vascular, pubmed-meshheading:7591287-Female, pubmed-meshheading:7591287-Heparin, pubmed-meshheading:7591287-Hydrocortisone, pubmed-meshheading:7591287-Laminin, pubmed-meshheading:7591287-Mice, pubmed-meshheading:7591287-Mice, Inbred C57BL, pubmed-meshheading:7591287-Neoplasm Transplantation, pubmed-meshheading:7591287-Neovascularization, Pathologic, pubmed-meshheading:7591287-Proteoglycans, pubmed-meshheading:7591287-Tumor Cells, Cultured
pubmed:year
1995
pubmed:articleTitle
Anti-tumor and anti-angiogenic effects in mice of heparin conjugated to angiostatic steroids.
pubmed:affiliation
Department of Pharmacology, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75235-8593, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't