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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1995-12-7
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pubmed:abstractText |
1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane model. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable attributes for ionophoretic activity across a hydrophobic environment. 3. It is speculated that the ionophoretic property of KAD-1229 might participate to the remodelling of cationic fluxes evoked by this insulinotropic agent in pancreatic islet cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0306-3623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1319-25
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7590126-Animals,
pubmed-meshheading:7590126-Calcium,
pubmed-meshheading:7590126-Cations,
pubmed-meshheading:7590126-Hypoglycemic Agents,
pubmed-meshheading:7590126-Indoles,
pubmed-meshheading:7590126-Ionophores,
pubmed-meshheading:7590126-Isoindoles,
pubmed-meshheading:7590126-Models, Molecular,
pubmed-meshheading:7590126-Molecular Structure,
pubmed-meshheading:7590126-Rats
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pubmed:year |
1995
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pubmed:articleTitle |
Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. II. Ionophoretic and conformational aspects.
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pubmed:affiliation |
Laboratoires de Médecine Expérimentale et de Chimie Physique des Macromolécules aux Interfaces, Brussels Free University, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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