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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1995-12-12
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pubmed:abstractText |
Allotype- or idiotype-specific CD4+ T cells have been reported to recognize immunoglobulin (Ig) peptides presented by class II molecules. In contrast, few data are available concerning the generation of Ig peptide-specific CD8+ T cells. We have therefore investigated whether T-depleted spleen cells from Ig kappa light chain-expressing 129/Sv mice (129 kappa +/+) could induce, in C kappa knockout mice (129 kappa -/-), the generation of Ig constant kappa light chain region (C kappa)-specific cytotoxic T lymphocytes (CTL). The determination of TCR beta chain expressed by nine CTL clones, together with the use of a library of overlapping peptides spanning the whole C kappa sequence, show that the B cells from kappa +/+ mice are able to elicit in C kappa knockout mice, the emergence of a diverse CTL repertoire that recognizes one single C kappa peptide presented by the H-2Kb class I molecule. In addition, these data support the notion that B cells are able to process and present on their class I molecules, peptides generated from their own kappa light chains.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2752-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7589067-Amino Acid Sequence,
pubmed-meshheading:7589067-Animals,
pubmed-meshheading:7589067-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7589067-Cell Transplantation,
pubmed-meshheading:7589067-Cytotoxicity, Immunologic,
pubmed-meshheading:7589067-Epitopes,
pubmed-meshheading:7589067-Genes, Immunoglobulin,
pubmed-meshheading:7589067-H-2 Antigens,
pubmed-meshheading:7589067-Immunoglobulin Constant Regions,
pubmed-meshheading:7589067-Immunoglobulin kappa-Chains,
pubmed-meshheading:7589067-Lymphoma,
pubmed-meshheading:7589067-Male,
pubmed-meshheading:7589067-Mice,
pubmed-meshheading:7589067-Mice, Knockout,
pubmed-meshheading:7589067-Molecular Sequence Data,
pubmed-meshheading:7589067-Peptide Fragments,
pubmed-meshheading:7589067-Rats,
pubmed-meshheading:7589067-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7589067-Spleen,
pubmed-meshheading:7589067-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:7589067-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Emergence in C kappa knockout mice of a diverse cytotoxic T lymphocyte repertoire that recognizes a single peptide from the immunoglobulin constant kappa light chain region.
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pubmed:affiliation |
Département d'Immunologie, Institut Pasteur (URA CNRS 1961 and Université Pierre et Marie Curie), Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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