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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1995-11-24
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pubmed:abstractText |
Mice homozygous for a disruption at the Lyn locus display abnormalities associated with the B lymphocyte lineage and in mast cell function. Despite reduced numbers of recirculating B lymphocytes, Lyn-/- mice are immunoglobulin M (IgM) hyperglobulinemic. Immune responses to T-independent and T-dependent antigens are affected. Lyn-/- mice fail to mediate an allergic response to IgE cross-linking, indicating that activation of LYN plays an indispensable role in Fc epsilon RI signaling. Lyn-/- mice have circulating autoreactive antibodies, and many show severe glomerulonephritis caused by the deposition of IgG immune complexes in the kidney, a pathology reminiscent of systemic lupus erythematosus. Collectively, these results implicate LYN as having an indispensable role in immunoglobulin-mediated signaling, particularly in establishing B cell tolerance.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0092-8674
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7585947-Anaphylaxis,
pubmed-meshheading:7585947-Animals,
pubmed-meshheading:7585947-Antibody Formation,
pubmed-meshheading:7585947-Autoimmune Diseases,
pubmed-meshheading:7585947-B-Lymphocytes,
pubmed-meshheading:7585947-Base Sequence,
pubmed-meshheading:7585947-Glomerulonephritis,
pubmed-meshheading:7585947-Immune System,
pubmed-meshheading:7585947-Immunoglobulin E,
pubmed-meshheading:7585947-Immunoglobulin M,
pubmed-meshheading:7585947-Kidney,
pubmed-meshheading:7585947-Lupus Erythematosus, Systemic,
pubmed-meshheading:7585947-Mice,
pubmed-meshheading:7585947-Mice, Mutant Strains,
pubmed-meshheading:7585947-Molecular Sequence Data,
pubmed-meshheading:7585947-src-Family Kinases
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pubmed:year |
1995
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pubmed:articleTitle |
Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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