Linked Life Data

7579194

Source:http://linkedlifedata.com/resource/pubmed/id/7579194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-12-26
pubmed:abstractText
Murine NK cells can reject allogenic or parental-strain bone marrow cells (BMC) in vivo and can lyse T lymphoblasts in vitro. The 'missing self' hypothesis states that absence or presence of 'negative signals' from target cell class I antigens (Ag) to NK receptors determines whether or not lysis occurs. Indeed, lysis of parental-strain blasts by purified F1 NK cell subsets occurred only in the presence of anti-receptor antibodies. Evidence for 'positive signaling' to NK cells by class I Ag includes rejection of D8 (Dd) transgene to B6) BMC by B6 hosts. The outcome of other BMC transplants contradict the missing self idea, because donors with identical class I Ag differ in compatibility with certain hosts. Perhaps class I Ag-NK cell receptor interactions dominate over other target-NK cell interactions. These interactions are usually 'negative' but can be 'positive'.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1044-5323
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Hybrid resistance: 'negative' and 'positive' signaling of murine natural killer cells.
pubmed:affiliation
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't