| pubmed-article:7578367 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7578367 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:7578367 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:7578367 | lifeskim:mentions | umls-concept:C0028953 | lld:lifeskim |
| pubmed-article:7578367 | lifeskim:mentions | umls-concept:C0032712 | lld:lifeskim |
| pubmed-article:7578367 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:7578367 | lifeskim:mentions | umls-concept:C1148806 | lld:lifeskim |
| pubmed-article:7578367 | lifeskim:mentions | umls-concept:C1521827 | lld:lifeskim |
| pubmed-article:7578367 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7578367 | pubmed:dateCreated | 1995-12-18 | lld:pubmed |
| pubmed-article:7578367 | pubmed:abstractText | A 5'-GCGAAAGC minihairpin structure was added to the 3'-end of an oligonucleotide substituted at the 5'-end by a manganese cationic porphyrin in order to enhance the 3'-exonuclease resistance of these cleaver-antisense molecules. The influence of this minihairpin on the 3'-exonuclease resistance, the binding affinity to a target ssDNA, and the cleaving efficiency of Mn-cationic porphyrin oligonucleotide conjugates was compared to that of the parent molecule without the 3'-hairpin. The results showed that the 3'-hairpin slightly decreased the binding affinity and consequently the cleaving efficiency of the conjugated molecule toward a target sequence, but the much higher nuclease resistance makes 3'-minihairpin-protected metalloporphyrin oligonucleotides good candidates as reactive antisense oligonucleotides for studies on cells. | lld:pubmed |
| pubmed-article:7578367 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7578367 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578367 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7578367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578367 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7578367 | pubmed:issn | 1043-1802 | lld:pubmed |
| pubmed-article:7578367 | pubmed:author | pubmed-author:MeunierBB | lld:pubmed |
| pubmed-article:7578367 | pubmed:author | pubmed-author:PratvielGG | lld:pubmed |
| pubmed-article:7578367 | pubmed:author | pubmed-author:MestreBB | lld:pubmed |
| pubmed-article:7578367 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7578367 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:7578367 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7578367 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7578367 | pubmed:pagination | 466-72 | lld:pubmed |
| pubmed-article:7578367 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7578367 | pubmed:meshHeading | pubmed-meshheading:7578367-... | lld:pubmed |
| pubmed-article:7578367 | pubmed:meshHeading | pubmed-meshheading:7578367-... | lld:pubmed |
| pubmed-article:7578367 | pubmed:meshHeading | pubmed-meshheading:7578367-... | lld:pubmed |
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| pubmed-article:7578367 | pubmed:meshHeading | pubmed-meshheading:7578367-... | lld:pubmed |
| pubmed-article:7578367 | pubmed:meshHeading | pubmed-meshheading:7578367-... | lld:pubmed |
| pubmed-article:7578367 | pubmed:meshHeading | pubmed-meshheading:7578367-... | lld:pubmed |
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| pubmed-article:7578367 | pubmed:meshHeading | pubmed-meshheading:7578367-... | lld:pubmed |
| pubmed-article:7578367 | pubmed:meshHeading | pubmed-meshheading:7578367-... | lld:pubmed |
| pubmed-article:7578367 | pubmed:articleTitle | Preparation and nuclease activity of hybrid "metallotris(methylpyridinium)porphyrin oligonucleotide" molecules having a 3'-loop for protection against 3'-exonucleases. | lld:pubmed |
| pubmed-article:7578367 | pubmed:affiliation | Laboratoire de Chimie de Coordination du CNRS, Toulouse, France. | lld:pubmed |
| pubmed-article:7578367 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7578367 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7578367 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7578367 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7578367 | lld:pubmed |
