Linked Life Data

7578032

Source:http://linkedlifedata.com/resource/pubmed/id/7578032

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
44
pubmed:dateCreated
1995-12-18
pubmed:abstractText
A novel nucleic acid secondary structure, exemplified by d(A(+)-G)10, is formed by an intramolecular, cooperative, acid-induced, coil-->helix transition. The helix is apparently left-handed, lacks base stacking and pairing, and is maintained by hydrogen and ionic bonds between dA+ "side-chain" residues (with electropositive hydrogens -N6H2, -N1+H) and the phosphodiester backbone. Modeling indicates that those dA+ residues lie approximately parallel to the helix axis, interacting with the n-1 backbone phosphates (with electronegative oxygens), somewhat like the -C=O...H-N- longitudinal interactions in a protein alpha-helix. Moreover, the intervening dG side-chain residues are extrahelical, as are amino acid side chains of an alpha-helix.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-2960
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14293-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Alpha-DNA, a single-stranded secondary structure stabilized by ionic and hydrogen bonds: d(A(+)-G)n.
pubmed:affiliation
Department of Molecular Biology, Princeton University, New Jersey 08544-1014, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't