Linked Life Data

7577164

Source:http://linkedlifedata.com/resource/pubmed/id/7577164

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-12-12
pubmed:abstractText
This study was performed in order to investigate the influence of skeletal unloading on the serum concentration of the carboxyl-terminal propeptide of type I procollagen (sPICP) and other markers of bone formation. Blood samples were taken every third hour from nine healthy premenopausal women (22-29 years) in two 24 h studies, before and at the end of five days of bed rest. Furthermore, a set of samples were taken 12 h apart after three days of bed rest. We measured sPICP, the serum concentration of intact and N-terminal-Mid fragment osteocalcin (sOC), and the serum concentration of alkaline phosphatase (sAP). During the five days of bed rest a gradual increase in sOC was observed, while sPICP gradually decreased. sAP was unchanged. Five days of best rest resulted in the following overall changes in the 24 h mean values: sPICP: -14% (p = 0.002); sOC: +9% (p = 0.009); sAP: -1% (not significant). The circadian patterns did not change significantly after bed rest. It is puzzling that the changes in the bone formation markers are of different magnitude, and for sPICP and sOC even in opposite directions. The increase in sOC may be caused by an increase in OC secretion by the osteoblasts or a release of bone-incorporated OC from resorbing sites; the accompanying decrease in sPICP may indicate that bone formation is actually transiently decreased after short term bed rest.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
8756-3282
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Changes in the carboxyl-terminal propeptide of type I procollagen and other markers of bone formation upon five days of bed rest.
pubmed:affiliation
Center for Clinical & Basic Research, Ballerup, Denmark.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial