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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5233
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pubmed:dateCreated |
1995-11-7
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pubmed:abstractText |
Major histocompatibility complex (MHC) class I molecules bind peptides that are delivered from the cytosol into the endoplasmic reticulum by the MHC-encoded transporter associated with antigen processing (TAP). Peptide capture by immature heterodimers of class I heavy chains and beta 2-microglobulin may be facilitated by their physical association with TAP. A genetic defect in a human mutant cell line causes the complete failure of diverse class I heterodimers to associate with TAP. This deficiency impairs the ability of the class I heterodimers to efficiently capture peptides and results from loss of function of an unidentified gene or genes linked to the MHC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Calnexin,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B5 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B8 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-G Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/TAP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TAP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
270
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7569935-ATP-Binding Cassette Transporters,
pubmed-meshheading:7569935-Amino Acid Sequence,
pubmed-meshheading:7569935-Calcium-Binding Proteins,
pubmed-meshheading:7569935-Calnexin,
pubmed-meshheading:7569935-Cell Line,
pubmed-meshheading:7569935-Endoplasmic Reticulum,
pubmed-meshheading:7569935-HLA Antigens,
pubmed-meshheading:7569935-HLA-A1 Antigen,
pubmed-meshheading:7569935-HLA-B Antigens,
pubmed-meshheading:7569935-HLA-B8 Antigen,
pubmed-meshheading:7569935-HLA-G Antigens,
pubmed-meshheading:7569935-Histocompatibility Antigens Class I,
pubmed-meshheading:7569935-Humans,
pubmed-meshheading:7569935-Ligands,
pubmed-meshheading:7569935-Major Histocompatibility Complex,
pubmed-meshheading:7569935-Molecular Sequence Data,
pubmed-meshheading:7569935-Mutation,
pubmed-meshheading:7569935-Peptides,
pubmed-meshheading:7569935-Transfection,
pubmed-meshheading:7569935-beta 2-Microglobulin
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pubmed:year |
1995
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pubmed:articleTitle |
Dependence of peptide binding by MHC class I molecules on their interaction with TAP.
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pubmed:affiliation |
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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