Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1995-10-23
pubmed:abstractText
Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor (NGF) gene family, has been shown to influence the survival and differentiation of specific classes of neurons in vitro and in vivo. The possibility that neurotrophins are also involved in processes of neuronal plasticity has only recently begun to receive attention. To determine whether BDNF has a function in processes such as long-term potentiation (LTP), we produced a strain of mice with a deletion in the coding sequence of the BDNF gene. We then used hippocampal slices from these mice to investigate whether LTP was affected by this mutation. Homo- and heterozygous mutant mice showed significantly reduced LTP in the CA1 region of the hippocampus. The magnitude of the potentiation, as well as the percentage of cases in which LTP could be induced successfully, was clearly affected. According to the criteria tested, important pharmacological, anatomical, and morphological parameters in the hippocampus of these animals appear to be normal. These results suggest that BDNF might have a functional role in the expression of LTP in the hippocampus.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-1331808, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-1409655, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-1463608, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-1713715, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-1829904, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-1924342, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-2054188, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-2133291, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-2549634, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-2571939, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-3306916, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-719524, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-7582095, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-7696574, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-7703418, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-7708216, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-7852989, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-7852991, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-7886457, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-7886458, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-8025717, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-8100368, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-8137432, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-8139657, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-8173317, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-8247360, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-8396461, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-8421494, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568031-8497318
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8856-60
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
pubmed:affiliation
Max-Planck-Institut für Psychiatrie, Munich-Martinsried, Germany.
pubmed:publicationType
Journal Article, In Vitro