Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6548
pubmed:dateCreated
1995-11-8
pubmed:databankReference
pubmed:abstractText
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Co-Repressor 1, http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin, http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine, http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid receptor beta
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
377
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
397-404
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:7566114-Amino Acid Sequence, pubmed-meshheading:7566114-Animals, pubmed-meshheading:7566114-Base Sequence, pubmed-meshheading:7566114-Binding Sites, pubmed-meshheading:7566114-Cell Line, pubmed-meshheading:7566114-DNA, pubmed-meshheading:7566114-Gene Expression Regulation, pubmed-meshheading:7566114-Humans, pubmed-meshheading:7566114-Ligands, pubmed-meshheading:7566114-Mice, pubmed-meshheading:7566114-Molecular Sequence Data, pubmed-meshheading:7566114-Mutagenesis, Site-Directed, pubmed-meshheading:7566114-Nuclear Proteins, pubmed-meshheading:7566114-Nuclear Receptor Co-Repressor 1, pubmed-meshheading:7566114-Oligodeoxyribonucleotides, pubmed-meshheading:7566114-Protein Binding, pubmed-meshheading:7566114-Receptors, Retinoic Acid, pubmed-meshheading:7566114-Receptors, Thyroid Hormone, pubmed-meshheading:7566114-Recombinant Fusion Proteins, pubmed-meshheading:7566114-Repressor Proteins, pubmed-meshheading:7566114-Transcription, Genetic, pubmed-meshheading:7566114-Transfection, pubmed-meshheading:7566114-Tretinoin, pubmed-meshheading:7566114-Triiodothyronine
pubmed:year
1995
pubmed:articleTitle
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.
pubmed:affiliation
Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0648, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't