Linked Life Data

7564969

Source:http://linkedlifedata.com/resource/pubmed/id/7564969

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1995-11-8
pubmed:abstractText
Nonmuscle cells play central roles in muscle repair and regeneration during the inflammation that follows muscle injury, although many aspects of the mechanisms by which inflammatory cells are attracted to injury sites and activated are unknown. Current evidence indicates that substances released from injured muscle can act as "wound hormones" that initiate inflammation. Most evidence supports the view that mononucleated cells that normally reside in muscle are activated by the injury, and then provide the chemotactic signal to circulating inflammatory cells. Three subsequent stages of inflammation can be identified, according to differences in the populations of inflammatory cells. First, neutrophils rapidly invade the injury site and promote inflammation by releasing cytokines that can attract and activate additional inflammatory cells. In at least some muscle injuries, neutrophils may further damage the injured muscle by releasing oxygen-free radicals that can damage cell membranes. Next, there is an increase in macrophages that invade damaged muscle fibers and phagocytose debris. Finally, there is an increase in a second subpopulation of macrophages that are associated with muscle regeneration. Although many of the potential mediators that underlie the proliferation, invasion, and activation of these inflammatory cell populations are known, few have been demonstrated conclusively to function in injured muscle in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0195-9131
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1022-32
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Inflammatory cell response to acute muscle injury.
pubmed:affiliation
Department of Physiological Science, University of California, Los Angeles 90095-1527, USA.
pubmed:publicationType
Journal Article, Review