|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1995-10-26
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Heat shock protein genes are induced by various kinds of stress. Besides stress, the heat shock family gene hsp70 has been shown to be induced by growth-stimulating agents such as the DNA virus oncoproteins and serum. Here, we report cloning of a novel cDNA that encodes a 100 kDa heat shock protein-related polypeptide as a human papillomavirus oncoprotein E7-inducible gene. E7 induces expression of this heat shock protein at the level of RNA synthesis. Moreover, the induction of this heat shock protein-mRNA was dependent on the conserved region 2 of the E7 protein, which is essential for binding to the proteins of the retinoblastoma family.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/HSP110 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HSP70 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hsp105 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Papillomavirus E7 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/oncogene protein E7, Human...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
11
|
|
pubmed:volume |
371
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
214-8
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:7556594-3T3 Cells,
pubmed-meshheading:7556594-Amino Acid Sequence,
pubmed-meshheading:7556594-Animals,
pubmed-meshheading:7556594-Base Sequence,
pubmed-meshheading:7556594-Cloning, Molecular,
pubmed-meshheading:7556594-DNA, Complementary,
pubmed-meshheading:7556594-Gene Expression Regulation,
pubmed-meshheading:7556594-HSP110 Heat-Shock Proteins,
pubmed-meshheading:7556594-HSP70 Heat-Shock Proteins,
pubmed-meshheading:7556594-Heat-Shock Response,
pubmed-meshheading:7556594-Humans,
pubmed-meshheading:7556594-Mice,
pubmed-meshheading:7556594-Molecular Sequence Data,
pubmed-meshheading:7556594-Mutation,
pubmed-meshheading:7556594-Oncogene Proteins, Viral,
pubmed-meshheading:7556594-Papillomavirus E7 Proteins,
pubmed-meshheading:7556594-RNA, Messenger,
pubmed-meshheading:7556594-Recombinant Proteins,
pubmed-meshheading:7556594-Sequence Homology, Amino Acid
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
HPV16 E7 oncoprotein induces expression of a 110 kDa heat shock protein.
|
|
pubmed:affiliation |
Department of Biochemistry (M/C 536), University of Illinois at Chicago 60612, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
