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pubmed-article:7552177pubmed:abstractTextThe subdivision of T cells into alpha beta and gamma delta subtypes is conserved throughout vertebrate development. The respective alpha beta and gamma delta T-cell receptors (TCRs) are encoded by somatically rearranged genes. There has been broad speculation as to whether an individual thymocyte can become either a gamma delta T cell or an alpha beta T cell as a result of stochastic gene rearrangement processes, or whether the two types of T cell are derived from separate lineages. Many of the experimental findings are apparently conflicting, however, and the issue--a basic one in immunology and development--remains unresolved.lld:pubmed
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pubmed-article:7552177pubmed:articleTitleAlpha beta and gamma delta T cells can share a late common precursor.lld:pubmed
pubmed-article:7552177pubmed:affiliationDepartment of Biology, Yale University, New Haven, Connecticut 06510, USA.lld:pubmed
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