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rdf:type |
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lifeskim:mentions |
umls-concept:C0039194,
umls-concept:C0205087,
umls-concept:C0205214,
umls-concept:C0237876,
umls-concept:C0330390,
umls-concept:C0439097,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1709634,
umls-concept:C1823153,
umls-concept:C2003941,
umls-concept:C2349976
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pubmed:issue |
6
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pubmed:dateCreated |
1995-11-3
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pubmed:abstractText |
The subdivision of T cells into alpha beta and gamma delta subtypes is conserved throughout vertebrate development. The respective alpha beta and gamma delta T-cell receptors (TCRs) are encoded by somatically rearranged genes. There has been broad speculation as to whether an individual thymocyte can become either a gamma delta T cell or an alpha beta T cell as a result of stochastic gene rearrangement processes, or whether the two types of T cell are derived from separate lineages. Many of the experimental findings are apparently conflicting, however, and the issue--a basic one in immunology and development--remains unresolved.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
659-69
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7552177-Animals,
pubmed-meshheading:7552177-Base Sequence,
pubmed-meshheading:7552177-Cell Differentiation,
pubmed-meshheading:7552177-DNA Nucleotidyltransferases,
pubmed-meshheading:7552177-Dendritic Cells,
pubmed-meshheading:7552177-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:7552177-Hematopoiesis,
pubmed-meshheading:7552177-Hematopoietic Stem Cells,
pubmed-meshheading:7552177-Mice,
pubmed-meshheading:7552177-Mice, Inbred C57BL,
pubmed-meshheading:7552177-Molecular Sequence Data,
pubmed-meshheading:7552177-Polymerase Chain Reaction,
pubmed-meshheading:7552177-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:7552177-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7552177-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:7552177-Stochastic Processes,
pubmed-meshheading:7552177-T-Lymphocyte Subsets,
pubmed-meshheading:7552177-VDJ Recombinases
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pubmed:year |
1995
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pubmed:articleTitle |
Alpha beta and gamma delta T cells can share a late common precursor.
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pubmed:affiliation |
Department of Biology, Yale University, New Haven, Connecticut 06510, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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