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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-11-13
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pubmed:abstractText |
The role of an androgen, dehydroepiandrosterone (DHEA) has been studied on the constitutive and IL-6 induced fibrinogen production of HepG-2 cells. DHEA markedly augments the constitutive fibrinogen production of the hepatoma cells in a dose dependent fashion. Oppositely, for IL-6 induced fibrinogen production, DHEA is strongly inhibitory. The effectiveness of DHEA on the constitutive fibrinogen production is further potentiated if the hepatoma cells are preincubated with a glucocorticosteroid, dexamethasone. These findings demonstrate that the complex interaction between the steroid- and cytokine-directed regulation of the production of acute phase proteins is further coloured by the action of androgens on immune and hormonal systems.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1217-8950
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
229-33
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7551718-Carcinoma, Hepatocellular,
pubmed-meshheading:7551718-Dehydroepiandrosterone,
pubmed-meshheading:7551718-Dexamethasone,
pubmed-meshheading:7551718-Fibrinogen,
pubmed-meshheading:7551718-Humans,
pubmed-meshheading:7551718-Immunologic Factors,
pubmed-meshheading:7551718-Interleukin-6,
pubmed-meshheading:7551718-Liver Neoplasms,
pubmed-meshheading:7551718-Recombinant Proteins,
pubmed-meshheading:7551718-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Dehydroepiandrosterone modulates the spontaneous and IL-6 stimulated fibrinogen production of human hepatoma cells.
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pubmed:affiliation |
Department of Molecular Biology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary.
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pubmed:publicationType |
Journal Article
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