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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1995-11-13
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pubmed:abstractText |
This study, which investigates prehepatectomy immunostimulation with recombinant interleukin-2 (rIL-2), had two goals: to evaluate the tolerance of rIL-2 in association with major hepatectomy, and to verify whether preoperative immunostimulation is effective (neoadjuvant immunotherapy). In animal experiments, the conjunction of shed tumor cells into the circulation during surgery and severe surgery-induced immunodepression can promote the dissemination of the disease. Perioperative immunostimulation by rIL-2 reduces the incidence of metastases in animals.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1072-7515
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
181
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
303-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7551323-Adenocarcinoma,
pubmed-meshheading:7551323-Adult,
pubmed-meshheading:7551323-Aged,
pubmed-meshheading:7551323-Colorectal Neoplasms,
pubmed-meshheading:7551323-Combined Modality Therapy,
pubmed-meshheading:7551323-Female,
pubmed-meshheading:7551323-Hepatectomy,
pubmed-meshheading:7551323-Humans,
pubmed-meshheading:7551323-Interleukin-2,
pubmed-meshheading:7551323-Liver Neoplasms,
pubmed-meshheading:7551323-Male,
pubmed-meshheading:7551323-Middle Aged,
pubmed-meshheading:7551323-Monitoring, Immunologic,
pubmed-meshheading:7551323-Preoperative Care,
pubmed-meshheading:7551323-Prospective Studies,
pubmed-meshheading:7551323-Recombinant Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
Phase I-II randomized study on prehepatectomy recombinant interleukin-2 immunotherapy in patients with metastatic carcinoma of the colon and rectum.
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pubmed:affiliation |
Department of Oncologic Digestive Surgery, Insitut Gustave Roussy, Villejuif-Paris, France.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II,
Clinical Trial, Phase I
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