Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
398
pubmed:dateCreated
1995-10-31
pubmed:abstractText
The majority of patients with dyspepsia are managed in general practice. However, most of the literature on Helicobacter pylori and its association with gastrointestinal disease has originated from secondary care. This review summarizes the role of H pylori in dyspepsia from the perspective of primary care and suggests a new strategy for the management of dyspeptic patients in this setting. Recent meta-analyses and consensus statements have supported the use of eradication therapy as first-line treatment of peptic ulceration. Studies from primary care have supported the use of eradication therapy in patients who have H pylori related peptic ulcer disease and require long-term H2-antagonist medication, on both clinical benefit and cost-effectiveness grounds. Of the many regimens proposed for the eradication of H pylori, the best evidence supports a triple combination of bismuth, metronidazole and tetracycline. Regimens using proton pump inhibitors may be more acceptable to patients but lack good evidence from trials. Use of a positive serum enzyme-linked immunoabsorbent assay for H pylori antibodies as a criterion for endoscopic investigation has been shown to result in a 23% reduction in endoscopic workload. Further research should answer questions of importance to general practitioners, such as the role of eradication therapy in patients with nonulcer dyspepsia and the effectiveness of eradication of H pylori in the prevention of gastric cancer.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1359263, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1437952, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1442673, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1449132, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1541426, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1606428, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1676478, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1727779, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1747644, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1754846, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1754858, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1891020, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1971318, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1974027, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-1991209, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-2059685, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-2207416, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-2249197, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-2890019, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-2904061, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-3058555, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-3217324, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-3373466, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-445096, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-6134060, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-6412895, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-7748649, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-7918928, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-7930425, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-7930437, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-7939433, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8047808, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8047818, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8047820, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8047831, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8053422, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8086990, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8098787, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8102009, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8126203, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8142828, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8150340, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8167491, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8171296, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8171300, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8265776, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8287341, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8341987, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8341988, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8341990, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8364136, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8406147, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8407699, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8409311, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8409329, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8411577, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8470623, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8470629, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8503319, http://linkedlifedata.com/resource/pubmed/commentcorrection/7546874-8745855
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0960-1643
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
489-94
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Role of Helicobacter pylori in gastrointestinal disease: implications for primary care of a revolution in management of dyspepsia.
pubmed:affiliation
Department of General Practice, University of Birmingham.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't