Linked Life Data

7545940

Source:http://linkedlifedata.com/resource/pubmed/id/7545940

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5171
pubmed:dateCreated
1994-8-15
pubmed:databankReference
pubmed:abstractText
When nutrients become limiting, many bacteria differentiate and become resistant to environmental stresses. For Escherichia coli, this process is mediated by the sigma s subunit of RNA polymerase. Expression of sigma s was induced by homoserine lactone, a metabolite synthesized from intermediates in threonine biosynthesis. Homoserine lactone-dependent synthesis of sigma s was prevented by overexpression of a newly identified protein, RspA. The function of homoserine lactone derivatives in many cell density-dependent phenomena and the similarity of RspA to a Streptomyces ambofaciens protein suggest that synthesis of homoserine lactone may be a general signal of starvation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
265
pubmed:geneSymbol
rpoS, rspA
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
537-9
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli.
pubmed:affiliation
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't