Linked Life Data

7545814

Source:http://linkedlifedata.com/resource/pubmed/id/7545814

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-10-19
pubmed:abstractText
Histopathologic features alone fail to reliably stratify patients with clinical Stage A nonseminomatous germ cell tumors of the testis into groups with high and low risk for occult metastatic disease. Previous flow cytometric studies at Indiana University demonstrated a significant correlation between high proliferative activity and metastatic disease. The current study evaluated the prognostic significance of immunohistochemical markers related to tumor proliferation and aggressiveness in a consecutive series of clinical Stage A nonseminomatous germ cell tumors patients who underwent retroperitoneal lymph node dissection. Archival material of the orchiectomy specimens of 62 patients (45 pathologic Stage A, 17 with metastatic disease) was reviewed and immunohistochemically stained for Ki-67 antigen (MIB-1), proliferation-associated nuclear antigen (PC10), p53 protein (Pab1801), and Factor-VIII-related antigen (neovascularization). Staining with MIB-1 was significantly higher in the metastatic group (mean 80.2%, standard deviation [SD] 15.5) than in pathologic Stage A cases (66.3%, SD 27.9; P = 0.0032) and was predictive of metastatic status with a sensitivity of 82% and specificity of 69%. In this study, no patient with a MIB-1 value less than 52% had metastases. Proliferation-associated nuclear antigen and p53 staining correlated with MIB-1 values (R = 0.63 and 0.55, respectively) but did not correlate with metastatic status. Tumor angiogenesis was also not predictive of metastatic status. Assessment of proliferation rates using MIB-1 antibody in clinical Stage A nonseminomatous germ-cell-tumor patients may prove helpful in predicting metastatic status.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0893-3952
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
492-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7545814-Germinoma, pubmed-meshheading:7545814-Humans, pubmed-meshheading:7545814-Immunohistochemistry, pubmed-meshheading:7545814-Ki-67 Antigen, pubmed-meshheading:7545814-Male, pubmed-meshheading:7545814-Neoplasm Proteins, pubmed-meshheading:7545814-Neoplasm Staging, pubmed-meshheading:7545814-Neovascularization, Pathologic, pubmed-meshheading:7545814-Nuclear Proteins, pubmed-meshheading:7545814-Prognosis, pubmed-meshheading:7545814-Proliferating Cell Nuclear Antigen, pubmed-meshheading:7545814-Retrospective Studies, pubmed-meshheading:7545814-Sensitivity and Specificity, pubmed-meshheading:7545814-Testicular Neoplasms, pubmed-meshheading:7545814-Tumor Markers, Biological, pubmed-meshheading:7545814-Tumor Suppressor Protein p53, pubmed-meshheading:7545814-von Willebrand Factor
pubmed:year
1995
pubmed:articleTitle
Prognostic significance of immunohistochemical proliferation markers (Ki-67/MIB-1 and proliferation-associated nuclear antigen), p53 protein accumulation, and neovascularization in clinical stage A nonseminomatous testicular germ cell tumors.
pubmed:affiliation
Department of Urology, Indiana University Medical Center, Indianapolis, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't