pubmed-article:7545313 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7545313 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
pubmed-article:7545313 | lifeskim:mentions | umls-concept:C0282498 | lld:lifeskim |
pubmed-article:7545313 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
pubmed-article:7545313 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
pubmed-article:7545313 | pubmed:issue | 5230 | lld:pubmed |
pubmed-article:7545313 | pubmed:dateCreated | 1995-10-12 | lld:pubmed |
pubmed-article:7545313 | pubmed:abstractText | Endogenously synthesized antigenic determinants are generally presented on major histocompatibility complex (MHC) class I molecules, whereas exogenous determinants are presented by MHC class II molecules. Here, it is shown that exogenous antigens chaperoned by a heat shock protein can be channeled into the endogenous pathway, presented by MHC class I molecules, and recognized by CD8+ T lymphocytes. This pathway is functional only in a subset of macrophages among the cell types tested. These observations provide a basis for the tumor-specific and virus-specific immunogenicity of cognate heat shock protein preparations and offer a mechanism for the classical phenomenon of cross-priming. | lld:pubmed |
pubmed-article:7545313 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7545313 | pubmed:language | eng | lld:pubmed |
pubmed-article:7545313 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7545313 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:7545313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:7545313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7545313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7545313 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7545313 | pubmed:month | Sep | lld:pubmed |
pubmed-article:7545313 | pubmed:issn | 0036-8075 | lld:pubmed |
pubmed-article:7545313 | pubmed:author | pubmed-author:SrivastavaP... | lld:pubmed |
pubmed-article:7545313 | pubmed:author | pubmed-author:SutoRR | lld:pubmed |
pubmed-article:7545313 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7545313 | pubmed:day | 15 | lld:pubmed |
pubmed-article:7545313 | pubmed:volume | 269 | lld:pubmed |
pubmed-article:7545313 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7545313 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7545313 | pubmed:pagination | 1585-8 | lld:pubmed |
pubmed-article:7545313 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:7545313 | pubmed:year | 1995 | lld:pubmed |
pubmed-article:7545313 | pubmed:articleTitle | A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. | lld:pubmed |
pubmed-article:7545313 | pubmed:affiliation | Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA. | lld:pubmed |
pubmed-article:7545313 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:7545313 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:7545313 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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