|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5230
|
|
pubmed:dateCreated |
1995-10-12
|
|
pubmed:abstractText |
Endogenously synthesized antigenic determinants are generally presented on major histocompatibility complex (MHC) class I molecules, whereas exogenous determinants are presented by MHC class II molecules. Here, it is shown that exogenous antigens chaperoned by a heat shock protein can be channeled into the endogenous pathway, presented by MHC class I molecules, and recognized by CD8+ T lymphocytes. This pathway is functional only in a subset of macrophages among the cell types tested. These observations provide a basis for the tumor-specific and virus-specific immunogenicity of cognate heat shock protein preparations and offer a mechanism for the classical phenomenon of cross-priming.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
269
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1585-8
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:7545313-Amino Acid Sequence,
pubmed-meshheading:7545313-Animals,
pubmed-meshheading:7545313-Antigen Presentation,
pubmed-meshheading:7545313-Antigens, Neoplasm,
pubmed-meshheading:7545313-Antigens, Viral,
pubmed-meshheading:7545313-Cells, Cultured,
pubmed-meshheading:7545313-Chaperonins,
pubmed-meshheading:7545313-Cytotoxicity, Immunologic,
pubmed-meshheading:7545313-Epitopes,
pubmed-meshheading:7545313-Histocompatibility Antigens Class I,
pubmed-meshheading:7545313-Macrophages,
pubmed-meshheading:7545313-Macrophages, Peritoneal,
pubmed-meshheading:7545313-Mice,
pubmed-meshheading:7545313-Mice, Inbred C57BL,
pubmed-meshheading:7545313-Molecular Sequence Data,
pubmed-meshheading:7545313-Peptides,
pubmed-meshheading:7545313-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:7545313-Transfection,
pubmed-meshheading:7545313-Tumor Necrosis Factor-alpha,
pubmed-meshheading:7545313-Vesicular stomatitis Indiana virus
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides.
|
|
pubmed:affiliation |
Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
