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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1995-8-29
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pubmed:abstractText |
The association of vitamin A supplementation with concentrations of positive acute-phase proteins in the serum was investigated in the Child Health Study of the Ghana Vitamin A Supplementation Trials, a randomized, controlled trial of the effect of vitamin A on morbidity in children aged < 5 y. Mean serum concentrations of alpha 1-acid glycoprotein, serum amyloid A, and C-reactive protein did not differ overall between the vitamin A-supplemented and placebo-treated groups. Treatment groups were then subdivided according to what symptoms children had experienced in the week before blood sampling. Acute-phase-protein responses to fever and cough were not affected by vitamin A supplementation. There was a tendency for vitamin A-supplemented children, but not placebo children, to have elevated acute-phase proteins in association with reported vomiting or severe diarrhea. The failure of unsupplemented children to mount an acute-phase response may have contributed to their increased morbidity from gastrointestinal symptoms.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acute-Phase Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Orosomucoid,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Amyloid A Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin A
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9165
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
434-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7542831-Acute-Phase Proteins,
pubmed-meshheading:7542831-C-Reactive Protein,
pubmed-meshheading:7542831-Child, Preschool,
pubmed-meshheading:7542831-Double-Blind Method,
pubmed-meshheading:7542831-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7542831-Food, Fortified,
pubmed-meshheading:7542831-Ghana,
pubmed-meshheading:7542831-Humans,
pubmed-meshheading:7542831-Infant,
pubmed-meshheading:7542831-Morbidity,
pubmed-meshheading:7542831-Orosomucoid,
pubmed-meshheading:7542831-Serum Amyloid A Protein,
pubmed-meshheading:7542831-Vitamin A
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pubmed:year |
1995
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pubmed:articleTitle |
Vitamin A supplementation, morbidity, and serum acute-phase proteins in young Ghanaian children.
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pubmed:affiliation |
International Child Health, Institute of Child Health, London, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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