rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5216
|
pubmed:dateCreated |
1995-7-5
|
pubmed:abstractText |
Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0036-8075
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
9
|
pubmed:volume |
268
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
N
|
pubmed:pagination |
1476-80
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:7539551-Amino Acid Sequence,
pubmed-meshheading:7539551-Bone Marrow Transplantation,
pubmed-meshheading:7539551-Epitopes,
pubmed-meshheading:7539551-Female,
pubmed-meshheading:7539551-Graft vs Host Disease,
pubmed-meshheading:7539551-HLA-A2 Antigen,
pubmed-meshheading:7539551-Humans,
pubmed-meshheading:7539551-Mass Spectrometry,
pubmed-meshheading:7539551-Minor Histocompatibility Antigens,
pubmed-meshheading:7539551-Molecular Sequence Data,
pubmed-meshheading:7539551-Neoplasm Proteins,
pubmed-meshheading:7539551-Oligopeptides,
pubmed-meshheading:7539551-T-Lymphocytes, Cytotoxic
|
pubmed:year |
1995
|
pubmed:articleTitle |
Identification of a graft versus host disease-associated human minor histocompatibility antigen.
|
pubmed:affiliation |
Department of Immunohaematology, University Hospital, Leiden, Netherlands.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|