|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5209
|
|
pubmed:dateCreated |
1995-5-18
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Fas is a cell surface receptor that controls a poorly understood signal transduction pathway that leads to cell death by means of apoptosis. A protein tyrosine phosphatase, FAP-1, capable of interacting with the cytosolic domain of Fas, was identified. The carboxyl terminal 15 amino acids of Fas are necessary and sufficient for interaction with FAP-1. FAP-1 expression is highest in tissues and cell lines that are relatively resistant to Fas-mediated cytotoxicity. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line. These findings are consistent with an inhibitory effect of FAP-1 on Fas signal transduction.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
21
|
|
pubmed:volume |
268
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
411-5
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7536343-Amino Acid Sequence,
pubmed-meshheading:7536343-Animals,
pubmed-meshheading:7536343-Antigens, CD95,
pubmed-meshheading:7536343-Antigens, Surface,
pubmed-meshheading:7536343-Apoptosis,
pubmed-meshheading:7536343-Base Sequence,
pubmed-meshheading:7536343-Cell Line,
pubmed-meshheading:7536343-Cloning, Molecular,
pubmed-meshheading:7536343-DNA, Complementary,
pubmed-meshheading:7536343-Humans,
pubmed-meshheading:7536343-Mice,
pubmed-meshheading:7536343-Molecular Sequence Data,
pubmed-meshheading:7536343-Protein Tyrosine Phosphatases,
pubmed-meshheading:7536343-Receptors, Cell Surface,
pubmed-meshheading:7536343-Recombinant Fusion Proteins,
pubmed-meshheading:7536343-Signal Transduction,
pubmed-meshheading:7536343-T-Lymphocytes
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
FAP-1: a protein tyrosine phosphatase that associates with Fas.
|
|
pubmed:affiliation |
La Jolla Cancer Research Foundation, Oncogene and Tumor Suppressor Gene Program, CA 92037, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
