Linked Life Data

7535692

Source:http://linkedlifedata.com/resource/pubmed/id/7535692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-11
pubmed:abstractText
The effects of low and clinically relevant concentrations of inhalation anaesthetics and related compounds on the firing behaviour of nerve axons from a number of species are described. The observation of substantial, if sometimes transient, changes in excitability is contrasted with the view that axonal ion channels are insensitive to many general anaesthetics. Taking the squid giant axon as a well-studied example, we show that a full understanding of these effects can only be achieved through a detailed investigation of the actions of a range of compounds on a number of ion channels. Small alterations in the properties of individual channel types can in combination result in major changes in the behaviour of a multi-channel system such as an axon. Finally, as an example of the spectrum of activity of structurally related compounds, we compare the effects of inhalation anaesthetics with those of volatile convulsants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0265-0215
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Integrative effects of general anaesthetics: why nerve axons should not be ignored.
pubmed:affiliation
Department of Anatomy & Physiology, The University, Dundee, UK.
pubmed:publicationType
Journal Article, Comparative Study, Review