| pubmed-article:7532023 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7532023 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7532023 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:7532023 | lifeskim:mentions | umls-concept:C0205991 | lld:lifeskim |
| pubmed-article:7532023 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:7532023 | lifeskim:mentions | umls-concept:C0617047 | lld:lifeskim |
| pubmed-article:7532023 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:7532023 | pubmed:dateCreated | 1995-3-23 | lld:pubmed |
| pubmed-article:7532023 | pubmed:abstractText | Partially desialylated ovine submaxillary mucin plus an immunological adjuvant has been used by us to induce a humoral immune response to Tn antigen and sialylated Tn in colon cancer patients at risk of recurrence. Peripheral blood lymphocytes were purified from one of these patients with a high IgM titer reactive with Tn antigen transformed with Epstein-Barr virus and subsequently fused with a human-mouse heteromyeloma cell line, HMMA2.11TG/O. Clones were screened and subcloned using an enzyme-linked immunoassay and four stable IgM-secreting clones were tested for reactivity with a variety of natural and synthetic antigens, paraffin-embedded colon carcinomas and normal colonic mucosa to determine their specificity. Four human IgM monoclonal antibodies reactive predominantly with Tn antigen were produced and shown to react with a mucinous human colon carcinoma cell line, LS-174T, and with paraffin-embedded human colon carcinomas. We conclude that modified ovine submaxillary mucin is an effective vaccine for generating a humoral immune response directed to Tn antigen present on human colon cancer. | lld:pubmed |
| pubmed-article:7532023 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7532023 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532023 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7532023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7532023 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7532023 | pubmed:issn | 0956-960X | lld:pubmed |
| pubmed-article:7532023 | pubmed:author | pubmed-author:WrightKK | lld:pubmed |
| pubmed-article:7532023 | pubmed:author | pubmed-author:O'BoyleK PKP | lld:pubmed |
| pubmed-article:7532023 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7532023 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:7532023 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7532023 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7532023 | pubmed:pagination | 25-31 | lld:pubmed |
| pubmed-article:7532023 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7532023 | pubmed:meshHeading | pubmed-meshheading:7532023-... | lld:pubmed |
| pubmed-article:7532023 | pubmed:meshHeading | pubmed-meshheading:7532023-... | lld:pubmed |
| pubmed-article:7532023 | pubmed:meshHeading | pubmed-meshheading:7532023-... | lld:pubmed |
| pubmed-article:7532023 | pubmed:meshHeading | pubmed-meshheading:7532023-... | lld:pubmed |
| pubmed-article:7532023 | pubmed:meshHeading | pubmed-meshheading:7532023-... | lld:pubmed |
| pubmed-article:7532023 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7532023 | pubmed:articleTitle | Anti-Tn human monoclonal antibodies generated following active immunization with partially desialylated ovine submaxillary mucin. | lld:pubmed |
| pubmed-article:7532023 | pubmed:affiliation | Montefiore Medical Center/Albert Einstein Cancer Center, Bronx, New York 10467. | lld:pubmed |
| pubmed-article:7532023 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7532023 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7532023 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7532023 | lld:pubmed |
