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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-11-30
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pubmed:abstractText |
The genes for insulin-like growth factor binding proteins (IGFBPs) encode secreted proteins that bind insulin-like growth factors I and II with high affinity and modulate their biological activities. In this report we have used interspecific backcross mapping and gene cloning to define the chromosomal locations of 4 mouse Igfbp genes. Igfbp1 and 3 are found in the proximal part of chromosome 1. In the human genome these two loci map within 20 kb of one another on chromosome 7p14-p12, and the genes are organized in a tail-to-tail configuration. Mouse Igfbp2 and 5 colocalize to a proximal region of chromosome 1 that is syntenic with human chromosome 2q33-q36, and the two genes are 5 kb apart in a tail-to-tail orientation. These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:geneSymbol |
Igfbp3,
Igfbp5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
653-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7525452-Animals,
pubmed-meshheading:7525452-Carrier Proteins,
pubmed-meshheading:7525452-Chromosome Mapping,
pubmed-meshheading:7525452-Chromosomes, Human, Pair 7,
pubmed-meshheading:7525452-Crosses, Genetic,
pubmed-meshheading:7525452-Female,
pubmed-meshheading:7525452-Genome, Human,
pubmed-meshheading:7525452-Humans,
pubmed-meshheading:7525452-Insulin-Like Growth Factor Binding Protein 1,
pubmed-meshheading:7525452-Insulin-Like Growth Factor Binding Protein 2,
pubmed-meshheading:7525452-Insulin-Like Growth Factor Binding Protein 5,
pubmed-meshheading:7525452-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:7525452-Male,
pubmed-meshheading:7525452-Mice,
pubmed-meshheading:7525452-Multigene Family,
pubmed-meshheading:7525452-Muridae,
pubmed-meshheading:7525452-Restriction Mapping,
pubmed-meshheading:7525452-Species Specificity
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pubmed:year |
1994
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pubmed:articleTitle |
Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11.
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pubmed:affiliation |
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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