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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0020963,
umls-concept:C0023516,
umls-concept:C0039195,
umls-concept:C0205263,
umls-concept:C0205307,
umls-concept:C0205369,
umls-concept:C0205430,
umls-concept:C0301625,
umls-concept:C0348011,
umls-concept:C1515138,
umls-concept:C1705822,
umls-concept:C1709854,
umls-concept:C1998793,
umls-concept:C2348628
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pubmed:issue |
1
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pubmed:dateCreated |
1978-4-26
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pubmed:abstractText |
Specific immune unresponsiveness against a given set of histocompatibility antigens can be induced by immunization with autologous, antigen-specific T lymphoblasts. Such unresponsiveness can be transferred by lymphoid cells from autoblast-immunized donors to normal syngeneic recipients. The cells being most efficient in transferring the selective suppression are T lymphocytes from the spleen, especially if of Ly 1-2+3+ phenotype. By using such T lymphocytes we deem it likely that the actual underlying mechanism is one of actual transfer of autoanti-idiotypic killer T cells. In support for this view is the fact that such T cells endowed with exquisite specific, cytolytic reactivity towards autologous idiotype-positive T target cells exist in autoblast immune animals. Significant suppression may also be transferred with T cells of Ly 1+2-3- phenotype or with B cells. Here, we consider the suppressive mechanism to be one of production of autoanti-idiotypic antibodies. By using affinity fraction procedures, it was finally possible to prove that all T-cell suppressive activity resides in a population with true antigen-binding-specific receptors for the relevant idiotypes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-1087700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-1092799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-11993330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-12245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-13877620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-302312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-4133807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-4551691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-4943147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-50400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-5075626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-53259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-53260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-55461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-5783244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-5944347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-68888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75236-75235
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
147
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-76
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:75236-Animals,
pubmed-meshheading:75236-Antibodies, Anti-Idiotypic,
pubmed-meshheading:75236-Antibody Specificity,
pubmed-meshheading:75236-Autoantibodies,
pubmed-meshheading:75236-Epitopes,
pubmed-meshheading:75236-Histocompatibility Antigens,
pubmed-meshheading:75236-Immune Tolerance,
pubmed-meshheading:75236-Immunoglobulins,
pubmed-meshheading:75236-Immunosuppression,
pubmed-meshheading:75236-Killer Cells, Natural,
pubmed-meshheading:75236-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:75236-Mice,
pubmed-meshheading:75236-Mice, Inbred Strains,
pubmed-meshheading:75236-T-Lymphocytes
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pubmed:year |
1978
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pubmed:articleTitle |
Induction of specific immune unresponsiveness with purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. III. Proof for the existence of autoanti-idiotypic killer T cells and transfer of suppression to normal syngeneic recipients by T or B lymphocytes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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