Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-10-31
pubmed:abstractText
Human adenovirus type 2 (Ad2) enters host cells by receptor-mediated endocytosis, an event mediated by the virus penton base binding to cell surface integrins alpha v beta 3 and alpha v beta 5. While both alpha v integrins promote virus internalization, alpha v beta 5 is involved in the subsequent event of membrane permeabilization. Cells transfected with the beta 5 or beta 3 subunit, expressing either alpha v beta 5 and alpha v beta 3, respectively, were capable of supporting Ad2 infection to varying degrees. In this case, cells expressing alpha v beta 5 were significantly more susceptible to Ad2-induced membrane permeabilization, as well as to Ad2 infection, than cells expressing alpha v beta 3. Adenovirus-mediated gene delivery was also more efficient in cells expressing alpha v beta 5. These results suggest that the interaction of alpha v beta 5 with Ad2 penton base facilitates the subsequent step of virus penetration into the cell. These studies provide evidence for the involvement of a cellular receptor in virus-mediated membrane permeabilization and suggest a novel biological role for integrin alpha v beta 5 in the infectious pathway of a human adenovirus.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-1370653, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-1487996, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-15938293, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-1681545, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-1709170, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-1920625, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-2017680, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-2328726, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-2333290, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-2433281, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-2447074, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-2879942, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-334160, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-3433922, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-3494014, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-3654825, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-3754765, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-4019489, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-4055783, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-4312064, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-5437781, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-5723709, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-574751, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-6333584, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-6334083, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-6471167, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-7241661, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-7681432, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-7682219, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-8221887, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-8334984, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-833922, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-8350395, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-8360273, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-8477447, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-8481237, http://linkedlifedata.com/resource/pubmed/commentcorrection/7523420-8486470
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-64
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.
pubmed:affiliation
Department of Immunology, Scripps Research Institute, La Jolla, California 92037.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.
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