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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-8-22
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pubmed:abstractText |
1. This study examined the effects of transforming growth factor-beta 1 (TGF-beta 1) on platelet-derived growth factor-BB (PDGF-BB)-stimulated DNA synthesis, [125I]-PDGF-BB receptor binding and PDGF-beta receptor mRNA expression in vascular smooth muscle cells (VSMC) isolated from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). 2. TGF-beta 1 inhibited by 40% DNA synthesis stimulated by PDGF-BB in VSMC from WKY rats but potentiated by 20% growth factor-stimulated DNA synthesis in VSMC from the SHR. 3. Since the difference in effect of TGF-beta 1 could not be attributed to differential regulation of [125I]-PDGF-BB binding activity and PDGF-beta receptor mRNA expression, it is suggested that alterations in intracellular signalling pathways may account for the differential effects of TGF-beta 1 on PDGF-BB-stimulated DNA synthesis in VSMC from SHR and WKY rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0305-1870
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7518757-Animals,
pubmed-meshheading:7518757-Cell Division,
pubmed-meshheading:7518757-Cells, Cultured,
pubmed-meshheading:7518757-DNA,
pubmed-meshheading:7518757-Gene Expression,
pubmed-meshheading:7518757-Iodine Radioisotopes,
pubmed-meshheading:7518757-Mitogens,
pubmed-meshheading:7518757-Muscle, Smooth, Vascular,
pubmed-meshheading:7518757-Platelet-Derived Growth Factor,
pubmed-meshheading:7518757-RNA,
pubmed-meshheading:7518757-Rats,
pubmed-meshheading:7518757-Rats, Inbred SHR,
pubmed-meshheading:7518757-Rats, Inbred WKY,
pubmed-meshheading:7518757-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:7518757-Thymidine,
pubmed-meshheading:7518757-Transforming Growth Factor beta
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pubmed:year |
1994
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pubmed:articleTitle |
Effect of transforming growth factor-beta 1 on platelet-derived growth factor receptor binding and gene expression in vascular smooth muscle cells from SHR and WKY rats.
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pubmed:affiliation |
Baker Medical Research Institute, Alfred Hospital, Prahran, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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