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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5167
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pubmed:dateCreated |
1994-7-18
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pubmed:abstractText |
Glycosyl-phosphatidylinositol (GPI)-anchored proteins have been reported to reside in clusters collected over small membrane invaginations called caveolae. The detection of different GPI-anchored proteins with fluorescently labeled monoclonal antibodies showed that these proteins are not constitutively concentrated in caveolae; they enter these structures independently after cross-linking with polyclonal secondary antibodies. Analysis of the cell surface distribution of the GPI-anchored folate receptor by electron microscopy confirms these observations. Thus, multimerization of GPI-anchored proteins regulates their sequestration in caveolae, but in the absence of agents that promote clustering they are diffusely distributed over the plasma membrane.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD55,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Thy-1,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolin 1,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolins,
http://linkedlifedata.com/resource/pubmed/chemical/Folate Receptors, GPI-Anchored,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosylphosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
264
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1948-51
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7516582-3T3 Cells,
pubmed-meshheading:7516582-Animals,
pubmed-meshheading:7516582-Antibodies, Monoclonal,
pubmed-meshheading:7516582-Antigens, CD,
pubmed-meshheading:7516582-Antigens, CD55,
pubmed-meshheading:7516582-Antigens, Surface,
pubmed-meshheading:7516582-Antigens, Thy-1,
pubmed-meshheading:7516582-Carrier Proteins,
pubmed-meshheading:7516582-Caveolin 1,
pubmed-meshheading:7516582-Caveolins,
pubmed-meshheading:7516582-Cell Membrane,
pubmed-meshheading:7516582-Fluorescent Antibody Technique,
pubmed-meshheading:7516582-Folate Receptors, GPI-Anchored,
pubmed-meshheading:7516582-Folic Acid,
pubmed-meshheading:7516582-Glycosylphosphatidylinositols,
pubmed-meshheading:7516582-Humans,
pubmed-meshheading:7516582-Immunoglobulin G,
pubmed-meshheading:7516582-Membrane Glycoproteins,
pubmed-meshheading:7516582-Membrane Proteins,
pubmed-meshheading:7516582-Mice,
pubmed-meshheading:7516582-Microscopy, Electron,
pubmed-meshheading:7516582-Receptors, Cell Surface,
pubmed-meshheading:7516582-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking.
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pubmed:affiliation |
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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