| pubmed-article:7514298 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7514298 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7514298 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:7514298 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:7514298 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:7514298 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:7514298 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:7514298 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:7514298 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:7514298 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7514298 | pubmed:dateCreated | 1994-6-16 | lld:pubmed |
| pubmed-article:7514298 | pubmed:abstractText | Human monocytes (M phi) require stimulation with substances such as bacterial endotoxin [LPS (lipopolysaccharide)] to produce angiogenic activity. In this study, we report that stimulation of M phi with LPS (5 micrograms/ml) in the absence of L-arginine greatly reduced their production of angiogenic activity, as assessed in vivo in rat corneas and in vitro by chemotaxis of human umbilical vein endothelial cells (HU-VECs). D-Arginine did not substitute for L-arginine in the production of angiogenic activity. The nitric oxide synthase (NO synthase, EC 1.14-13.39) inhibitors NG-monomethyl-L-arginine (L-NMMA) and NG-nitro-L-arginine methyl ester (L-NAME) both inhibited the production of angiogenic activity by LPS-stimulated M phi in the presence of L-arginine, suggesting the involvement of this enzyme in the pathway that generates angiogenic activity. Neither of these substances directly inhibited the M phi-derived angiogenic activity. LPS-induced production of the cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin 8 (IL-8) was not significantly reduced when M phi were incubated in the absence of L-arginine. Similarly, L-NMMA and L-NAME did not significantly reduce the LPS-induced production of these cytokines by M phi in the presence of L-arginine. These results suggest that the LPS-stimulation-dependent generation of angiogenic activity by M phi requires an L-arginine-dependent NO-synthase effector mechanism that may be independent of the generation of TNF-alpha and IL-8. | lld:pubmed |
| pubmed-article:7514298 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7514298 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514298 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7514298 | pubmed:month | May | lld:pubmed |
| pubmed-article:7514298 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7514298 | pubmed:author | pubmed-author:LeibovichS... | lld:pubmed |
| pubmed-article:7514298 | pubmed:author | pubmed-author:PolveriniP... | lld:pubmed |
| pubmed-article:7514298 | pubmed:author | pubmed-author:FongT WTW | lld:pubmed |
| pubmed-article:7514298 | pubmed:author | pubmed-author:KochA EAE | lld:pubmed |
| pubmed-article:7514298 | pubmed:author | pubmed-author:HarlowL ALA | lld:pubmed |
| pubmed-article:7514298 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7514298 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:7514298 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:7514298 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7514298 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7514298 | pubmed:pagination | 4190-4 | lld:pubmed |
| pubmed-article:7514298 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
| pubmed-article:7514298 | pubmed:meshHeading | pubmed-meshheading:7514298-... | lld:pubmed |
