rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1994-6-16
|
pubmed:abstractText |
The risk of Down's syndrome pregnancies can be estimated by quantitation of maternal serum markers, namely alpha-fetoprotein, unconjugated estriol and human chorionic gonadotropin (triple test). A prospective study of 2892 pregnant women (median age 33.5 years) is reported. The detection rate of Down's syndrome pregnancies was 80% (confidence intervals 45%-100%) when a risk of 1:380 or greater was considered "screen positive", the false positive rate was 13.3% (confidence intervals 12.0%-14.5%). The importance of the accurate assessment of gestational age and the time of blood sampling are emphasized. Our findings are compared with similar studies performed in other laboratories.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0940-5437
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
24
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
N
|
pubmed:pagination |
49-53
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7514056-Adult,
pubmed-meshheading:7514056-Amniocentesis,
pubmed-meshheading:7514056-Biological Markers,
pubmed-meshheading:7514056-Chorionic Gonadotropin,
pubmed-meshheading:7514056-Cohort Studies,
pubmed-meshheading:7514056-Down Syndrome,
pubmed-meshheading:7514056-Estriol,
pubmed-meshheading:7514056-False Positive Reactions,
pubmed-meshheading:7514056-Female,
pubmed-meshheading:7514056-Gestational Age,
pubmed-meshheading:7514056-Humans,
pubmed-meshheading:7514056-Karyotyping,
pubmed-meshheading:7514056-Mass Screening,
pubmed-meshheading:7514056-Maternal Age,
pubmed-meshheading:7514056-Pregnancy,
pubmed-meshheading:7514056-Pregnancy, High-Risk,
pubmed-meshheading:7514056-Prenatal Diagnosis,
pubmed-meshheading:7514056-Prospective Studies,
pubmed-meshheading:7514056-Risk,
pubmed-meshheading:7514056-alpha-Fetoproteins
|
pubmed:year |
1994
|
pubmed:articleTitle |
Maternal serum markers. Estimation of the risk of Down's syndrome: a prospective study.
|
pubmed:affiliation |
Ente Ospedaliero Sant'Anna, USL-IX, Turin, Italy.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|