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rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-5-4
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pubmed:abstractText |
A study of the histopathological abnormalities in a case of alopecia universalis was accompanied by immunohistochemical analysis of the expression of intercellular adhesion molecule-1 (ICAM-1) and E-selectin (formerly known as endothelial leukocyte adhesion molecule-1) within the skin. ICAM-1 expression on follicular epithelium co-localized with intraepithelial mononuclear cells (MNC) positive for the interleukin-2 receptor alpha-chain (IL-2R) or HLA-DR. Aberrant expression of E-selectin was observed on dermal endothelium. Although restricted to one case, these new observations concerning the expression of E-selectin and IL-2R in alopecia universalis are consistent with the view that extravascular trafficking of MNC into follicular epithelium may play a key role in the pathogenesis of alopecia universalis and that use of agents that interfere with this process may be an effective therapeutic strategy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0001-5555
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7511865-Adult,
pubmed-meshheading:7511865-Alopecia,
pubmed-meshheading:7511865-Antigens, CD,
pubmed-meshheading:7511865-Cell Adhesion Molecules,
pubmed-meshheading:7511865-E-Selectin,
pubmed-meshheading:7511865-Epithelium,
pubmed-meshheading:7511865-Female,
pubmed-meshheading:7511865-Hair,
pubmed-meshheading:7511865-Humans,
pubmed-meshheading:7511865-Intercellular Adhesion Molecule-1,
pubmed-meshheading:7511865-Leukocytes, Mononuclear,
pubmed-meshheading:7511865-Receptors, Immunologic,
pubmed-meshheading:7511865-Receptors, Interleukin-2
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|
pubmed:year |
1994
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|
pubmed:articleTitle |
E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis.
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pubmed:affiliation |
Department of Surgery, University of Pittsburgh Medical Center, PA.
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pubmed:publicationType |
Journal Article,
Case Reports
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