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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1994-3-10
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pubmed:abstractText |
We isolated two candidates for endogenous digitalis-like factors from human urine based on the inhibition of [3H]ouabain binding to intact human erythrocytes. The more-polar ouabain-displacing compound-1 (ODC-1) closely resembled ouabain in biological, physicochemical, and chromatographic properties. Moreover, anti-ouabain IgG dose-dependently neutralized the action of ODC-1. The less-polar ODC-2 behaved identically to digoxin in three analytical high-performance liquid chromatography and thin layer chromatography systems. Fast atom bombardment mass spectrum and proton nuclear magnetic resonance spectrum supported the notion that ODC-2 may be indistinguishable from digoxin. The possibility that substances quite similar to cardenolides are synthesized in the mammalian body must be seriously considered.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0160-2446
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22 Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S58-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7508030-Binding Sites,
pubmed-meshheading:7508030-Biological Factors,
pubmed-meshheading:7508030-Blood Proteins,
pubmed-meshheading:7508030-Cardenolides,
pubmed-meshheading:7508030-Chromatography, High Pressure Liquid,
pubmed-meshheading:7508030-Chromatography, Thin Layer,
pubmed-meshheading:7508030-Digoxin,
pubmed-meshheading:7508030-Erythrocytes,
pubmed-meshheading:7508030-Humans,
pubmed-meshheading:7508030-Immunoglobulin G,
pubmed-meshheading:7508030-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7508030-Male,
pubmed-meshheading:7508030-Ouabain,
pubmed-meshheading:7508030-Saponins,
pubmed-meshheading:7508030-Sodium-Potassium-Exchanging ATPase
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pubmed:year |
1993
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pubmed:articleTitle |
Digitalis-like factors from human urine.
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pubmed:affiliation |
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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