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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1994-3-9
|
| pubmed:abstractText |
Virus-induced changes in adhesion molecule expression on T cells were investigated to understand how antiviral effector cells migrate into infectious foci. FACS analysis revealed that after systemic infection with lymphocytic choriomeningitis virus a number of cell adhesion molecules, including VLA-4, LFA-1, and ICAM-1, are up-regulated on CD8+ cells, whereas the lymph node homing receptor MEL-14 is down-regulated during the infection; only marginal changes were observed for CD4+ cells. Basically similar but less marked results were obtained in mice infected with Pichinde virus. Further analyses showed that T cells with a changed adhesion molecule profile tended to present other cell surface markers indicating a state of cellular activation, e.g., IL-2R, and included all virus-specific CTL effectors. Regarding the physiologic significance of these changes in adhesion molecule expression, it was found that up-regulation of VLA-4 expression on splenic T cells correlated with influx of inflammatory cells into the cerebrospinal fluid of intracerebrally infected animals, and that the number of CD8+VLA-4hi cells increased from lymph nodes and spleen to blood and cerebrospinal fluid. These results support the hypothesis that up-regulation of VLA-4 is important for effector T cell homing to sites of inflammation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/L-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Very Late Antigen
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
152
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1237-45
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7507962-Animals,
pubmed-meshheading:7507962-Antigens, CD8,
pubmed-meshheading:7507962-Cell Adhesion Molecules,
pubmed-meshheading:7507962-Cerebrospinal Fluid,
pubmed-meshheading:7507962-Cytotoxicity, Immunologic,
pubmed-meshheading:7507962-Female,
pubmed-meshheading:7507962-Flow Cytometry,
pubmed-meshheading:7507962-Intercellular Adhesion Molecule-1,
pubmed-meshheading:7507962-L-Selectin,
pubmed-meshheading:7507962-Lymphocyte Activation,
pubmed-meshheading:7507962-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:7507962-Lymphocytic Choriomeningitis,
pubmed-meshheading:7507962-Mice,
pubmed-meshheading:7507962-Mice, Inbred BALB C,
pubmed-meshheading:7507962-Mice, Inbred C3H,
pubmed-meshheading:7507962-Mice, Inbred C57BL,
pubmed-meshheading:7507962-Receptors, Very Late Antigen,
pubmed-meshheading:7507962-T-Lymphocyte Subsets,
pubmed-meshheading:7507962-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Changes in cell adhesion molecule expression on T cells associated with systemic virus infection.
|
| pubmed:affiliation |
Institute of Medical Microbiology and Immunology, University of Copenhagen, Panum Institute, Denmark.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|