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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-3-1
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pubmed:abstractText |
We have identified a putative cGMP-gated cation conductance in rat retinal ganglion cells. Both in situ hybridization and polymerase chain reaction amplification detected transcripts in ganglion cells that were highly homologous to the cGMP-gated cation channel expressed in rod photoreceptors. Whole-cell patch-clamp recordings detected a current stimulated by cGMP due to activation of nonselective cation channels. This current had a reversal potential near 0 mV, showed some outward rectification, and could be blocked by Cd2+. The current could also be activated by a phosphodiesterase inhibitor and the nitric oxide donors sodium nitroprusside and S-nitrosocysteine. We propose that nitric oxide released from an identified subpopulation of amacrine cells may activate this channel to modulate ganglion cell activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-3-isobutylxanthine,
http://linkedlifedata.com/resource/pubmed/chemical/8-Bromo Cyclic Adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide-Gated Cation...,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/S-Nitrosothiols,
http://linkedlifedata.com/resource/pubmed/chemical/S-nitrosocysteine
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-65
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7507337-1-Methyl-3-isobutylxanthine,
pubmed-meshheading:7507337-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:7507337-Animals,
pubmed-meshheading:7507337-Animals, Newborn,
pubmed-meshheading:7507337-Base Sequence,
pubmed-meshheading:7507337-Cells, Cultured,
pubmed-meshheading:7507337-Cyclic GMP,
pubmed-meshheading:7507337-Cyclic Nucleotide-Gated Cation Channels,
pubmed-meshheading:7507337-Cysteine,
pubmed-meshheading:7507337-DNA Primers,
pubmed-meshheading:7507337-Electric Conductivity,
pubmed-meshheading:7507337-Gene Expression,
pubmed-meshheading:7507337-In Situ Hybridization,
pubmed-meshheading:7507337-Ion Channels,
pubmed-meshheading:7507337-Membrane Potentials,
pubmed-meshheading:7507337-Models, Neurological,
pubmed-meshheading:7507337-Molecular Sequence Data,
pubmed-meshheading:7507337-Nitric Oxide,
pubmed-meshheading:7507337-Nitroprusside,
pubmed-meshheading:7507337-Polymerase Chain Reaction,
pubmed-meshheading:7507337-Rats,
pubmed-meshheading:7507337-Rats, Wistar,
pubmed-meshheading:7507337-Retinal Ganglion Cells,
pubmed-meshheading:7507337-Retinal Rod Photoreceptor Cells,
pubmed-meshheading:7507337-S-Nitrosothiols,
pubmed-meshheading:7507337-Transcription, Genetic
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pubmed:year |
1994
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pubmed:articleTitle |
Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors.
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pubmed:affiliation |
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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