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rdf:type |
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lifeskim:mentions |
umls-concept:C0004572,
umls-concept:C0007600,
umls-concept:C0039194,
umls-concept:C0205245,
umls-concept:C0205409,
umls-concept:C0439097,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C1880022,
umls-concept:C2349976
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pubmed:issue |
1
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pubmed:dateCreated |
1994-2-22
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pubmed:abstractText |
Functional studies with WC1+ gamma/delta T cell lines were performed to clarify the role of this subpopulation of gamma/delta T cells in the in vitro immune response to Babesia bovis. As CD4+ T cells decreased and gamma/delta T cells increased in B. bovis-stimulated T cell lines, antigen-specific proliferation declined to background levels. One irradiated gamma/delta T cell line inhibited proliferation of autologous Th1 cells, although unirradiated gamma/delta T cells either synergized with or had no effect on Th cell proliferation. gamma/delta T cells were not cytolytic for bovine alpha/beta T cells, but expressed natural killer (NK)-like cytotoxicity when assayed on xenogeneic NK-sensitive target cells. The gamma/delta T cells were IL-2 dependent and expressed IFN-gamma and TNF-alpha, but not TNF-beta, IL-2, or IL-4 mRNA. Together, these results raise the possibility that WC1+ gamma/delta T cells respond in vitro to autoantigens present on CD4+ T cells or to cytokines secreted by activated CD4+ T cells, resulting in modulation of the CD4+ T cell response and outgrowth of the gamma/delta T cells in parasite-stimulated lines.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/L-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
153
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9-27
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7507005-Animals,
pubmed-meshheading:7507005-Antigens, CD45,
pubmed-meshheading:7507005-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:7507005-Antigens, Protozoan,
pubmed-meshheading:7507005-Babesia bovis,
pubmed-meshheading:7507005-Cattle,
pubmed-meshheading:7507005-Cell Adhesion Molecules,
pubmed-meshheading:7507005-Cell Line,
pubmed-meshheading:7507005-Cytokines,
pubmed-meshheading:7507005-Cytotoxicity, Immunologic,
pubmed-meshheading:7507005-Gene Expression,
pubmed-meshheading:7507005-Interferon-gamma,
pubmed-meshheading:7507005-L-Selectin,
pubmed-meshheading:7507005-Lymphocyte Activation,
pubmed-meshheading:7507005-RNA, Messenger,
pubmed-meshheading:7507005-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:7507005-T-Lymphocyte Subsets,
pubmed-meshheading:7507005-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:7507005-Tumor Necrosis Factor-alpha
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pubmed:year |
1994
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pubmed:articleTitle |
Functional and phenotypic characterization of WC1+ gamma/delta T cells isolated from Babesia bovis-stimulated T cell lines.
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pubmed:affiliation |
Department of Veterinary Pathobiology, Texas A & M University, College Station 77843.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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